GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7116495 | 1 | rs7127865 | chr11:71747781 | FAM86C | chr11:71498557-71512276:+ | 0.32 | 3.91 | 0.000107 | Severe influenza A (H1N1) infection |
| THCA | cis | rs7104764 | 1 | rs7128029 | chr11:244141 | PSMD13 | chr11:236808-252984:+ | -0.22 | -6.73 | 4.91E-11 | Menarche (age at onset) |
| THCA | cis | rs7104764 | 1 | rs7128029 | chr11:244141 | SIRT3 | chr11:214625-236931:- | 0.12 | 3.37 | 0.000812 | Menarche (age at onset) |
| THCA | cis | rs7104764 | 1 | rs7128044 | chr11:244115 | PSMD13 | chr11:236808-252984:+ | -0.22 | -6.73 | 4.91E-11 | Menarche (age at onset) |
| THCA | cis | rs7104764 | 1 | rs7128044 | chr11:244115 | SIRT3 | chr11:214625-236931:- | 0.12 | 3.37 | 0.000812 | Menarche (age at onset) |
| THCA | cis | rs7116495 | 1 | rs7128317 | chr11:71701367 | FAM86C | chr11:71498557-71512276:+ | -0.3 | -3.66 | 0.00028 | Severe influenza A (H1N1) infection |
| THCA | cis | rs7107174 | 1 | rs7128666 | chr11:78102363 | NARS2 | chr11:78147017-78285909:- | -0.4 | -7.06 | 5.95E-12 | Testicular germ cell tumor |
| THCA | cis | rs11603691 | 1 | rs7129491 | chr11:57095082 | TIMM10 | chr11:57295936-57298232:- | -0.24 | -4.38 | 1.49E-5 | Low high density lipoprotein cholesterol levels |
| THCA | cis | rs7129556 | 1 | rs7129556 | chr11:77300048 | AQP11 | chr11:77300436-77320691:+ | -0.4 | -6.19 | 1.26E-9 | Weight loss (gastric bypass surgery) |
| THCA | cis | rs3796352 | 1 | rs71299622 | chr3:52917038 | RFT1 | chr3:53122503-53164470:- | 0.61 | 6.95 | 1.18E-11 | Immune reponse to smallpox (secreted IL-2) |
| THCA | cis | rs3796352 | 1 | rs71299622 | chr3:52917038 | TMEM110 | chr3:52867139-52931547:- | 0.41 | 4.71 | 3.28E-6 | Immune reponse to smallpox (secreted IL-2) |
| THCA | cis | rs3796352 | 1 | rs71301804 | chr3:53073314 | RFT1 | chr3:53122503-53164470:- | 0.58 | 6.72 | 5.1E-11 | Immune reponse to smallpox (secreted IL-2) |
| THCA | cis | rs3796352 | 1 | rs71301804 | chr3:53073314 | TMEM110 | chr3:52867139-52931547:- | 0.35 | 4.05 | 6.03E-5 | Immune reponse to smallpox (secreted IL-2) |
| THCA | cis | rs3796352 | 1 | rs71301808 | chr3:53085577 | RFT1 | chr3:53122503-53164470:- | 0.64 | 7.57 | 2.0E-13 | Immune reponse to smallpox (secreted IL-2) |
| THCA | cis | rs3796352 | 1 | rs71301808 | chr3:53085577 | TMEM110 | chr3:52867139-52931547:- | 0.32 | 3.8 | 0.000167 | Immune reponse to smallpox (secreted IL-2) |